An Atlas of Differential Diagnosis in Neoplastic by Wojciech Gorczyca

By Wojciech Gorczyca

This vast reference overlaying neoplastic hematopathology contains over 500 color illustrations depicting hematopoietic tumors related to lymph nodes, spleen, bone marrow, and in most cases affected extranodal organs, with targeted emphasis at the differential prognosis. It discusses simple scientific, prognostic, morphologic and phenotypic facts, with quite a few tables summarizing the phenotypic profiles of the most typical hematologic tumors. an immense function of this ebook is an method of hematologic tumors in accordance with the WHO class, with proper examples and emphasis at the Most worthy morphologic and immunophenotypic positive factors utilized in diagnosis.It may be a useful reference for all training hematologists, oncologists and pathologists.

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The latter are monoclonal lambda+ cells, representing follicular lymphoma. Residual benign B-cells with moderate CD20 expression are polytypic (compare B and C). The two populations differ not only in respect to the intensity of CD20 expression but also by forward scatter, which corresponds to cell size (D and E). Gating on cells with moderate CD20 and low forward scatter (D) yields polytypic cells (see histograms on the right). Gating on cells with bright CD20 expression and slightly higher forward scatter (E) yields monoclonal lambda+ population (arrow, histograms on the right).

CD117 is usually negative on monocytic cells, B-ALL and most cases of blastic NK-cell lymphoma/leukemia and T-ALL. INTRODUCTION TO CYTOGENETICS/ MOLECULAR PATHOLOGY Cytogenetic/fluorescence in situ hybridization (FISH) and molecular tests, including polymerase chain reaction (PCR) and Southern blot are an integral part of evaluating hematopoietic tumors36,42–71. Detection of specific chromosomal changes is necessary for the diagnosis of chronic myeloid leukemia (Philadelphia chromosome leading to bcr-abl fusion gene), acute promyelocytic leukemia [t(15;17)], AML with t(8;21), Tprolymphocytic leukemia (chromosome 16 abnormalities), follicular lymphoma [t(14;18)] and Burkitt lymphoma (c-myc).

Classical Hodgkin lymphoma and NLPHL are often associated with an increased CD4:CD8 ratio (A). 5% 30% *All cases of CD117+ tumors were CD8+; X=not evaluated; CD10 expression in angioimmunoblastic lymphoma corresponds to cases in which majority of tumor cells were CD10+. 5%) and lack of CD7 (58% vs 98%) than T-ALL/LBL. The presence of CD1a, CD13, CD33, CD34, and TdT indicates T-ALL/LBL. 10 summarizes FC phenotypic characteristics of different types of acute leukemias. The majority of acute leukemias have blasts with low orthogonal side scatter (SSC), whereas all cases of hypergranular variants of APL are characterized by high SSC (similar to maturing granulocytes).

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