By Ana Catarina Mamede, Maria Filomena Botelho
This publication describes the human amniotic membrane from its beginning, characterization and scientific functions, summarizing the entire most modern advancements and findings concerning this tissue with contributions from a few of the major researchers within the box. The booklet addresses concerns for its upkeep, separation and identity of amniotic membrane-derived cells, in addition to the aptitude moral concerns excited by their use. the subject of this e-book is very pertinent for clinicians and researchers considering the examine and use of this tissue.
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Extra info for Amniotic Membrane: Origin, Characterization and Medical Applications
The major tensile strength of the amniotic membrane is provided by the collagens of the compact layer beneath the amniotic epithelium. However, this arrangement of interstitial collagens beneath and connected to the collagens of the amniotic basement membrane provides extra strength in tissue exposed to mechanical forces . ECM materials form the structural components of the architecture of the amniotic membrane and contain a variety of specialized proteins . Collagen and proteoglycan molecules are, along with elastin, fibronectin and laminin, the major components of the amniotic membrane ECM, accounting for the tissue integrity and mechanical properties .
Niknejad H, Yazdanpanah G, Mirmasoumi M et al (2013) Inhibition of HSP90 could be possible mechanism for anti-cancer property of amniotic membrane. Med Hypotheses 81:862–865 12. Li W, He H, Kawakita T et al (2006) Amniotic membrane induces apoptosis of interferongamma activated macrophages in vitro. Exp Eye Res 82:282–292 13. Seo JH, Kim YH, Kim JS (2008) Properties of the amniotic membrane may be applicable in cancer therapy. Med Hypotheses 70:812–814 14. Ganatra M (2003) Amniotic membrane in surgery.
Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. 2 (continued) Protein Cytokeratin 1 Symbol KRT1 Cytokeratin 19 KRT19 Cytosol aminopeptidase LAP3 Destrin DSTN Elongation factor 2 EEF2 Endoplasmic reticulum protein ERp29 precursor ERP29 Endoplasmin precursor HSP90B1 Esterase D ESD Ezrin EZR Fascin FSCN Fatty acid-binding protein, epidermal FABP5 Ferritin light chain FTL Function (UniProtKB/Swiss-Prot) May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/ GNB2L1) Involved in the organization of myofibers Presumably involved in the processing and regular turnover of intracellular proteins.