By T. Haferlach, C. Schoch, W. Hiddemann (auth.), Prof. Dr. med. Wolfgang Hiddemann, Prof. Dr. Dr. med. phil. Torsten Haferlach, Dr. med. Michael Unterhalt, Prof. Dr. med. Thomas Büchner, Prof. Dr. med. Jörg Ritter (eds.)
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Additional resources for Acute Leukemias IX: Basic Research, Experimental Approaches and Novel Therapies
Proc Nat! Acad Sci USA 97(13):7521-6 Miyamoto T et al. (2000) AMLl/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. Proc Nat! Acad Sci USA 97(13):7521-6 Okuda T et al. (1998) Expression of a knocked-in AMLl-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors. Blood 91(9):3134-43 27 Inducible AML l/ETO Expression in U-937 Myeloid Cells: a Model to Identify Genes Targeted by the Leukemia-Specific Fusion Protein Abstract Introduction The AMLl gene is fused to the ETO gene in a frequent, nonrandom chromosomal translocation t(8;21) in AML with maturation.
Bardwell, V. , Lavinsky, R. , Rosenfeld, M. , et al. (1998b). ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors, Mol Cell BioI 18,7176-84. , and Hiebert, S. W. (1995). The t(8;21) fusion protein interferes with AML-IBdependent transcriptional activation, Molecular & Cellular Biology 15, 1974-82. , and Ohki, M. (1993). The t(8;21) translocation in acute myeloid leukemia results in production of an AMLl-MTG8 fusion transcript, Embo I 12,2715-2721. , and Ohki, M.
Laherty, C. , Yang, W. , Ngo, S. , Davie, I. , et al. (1997). A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression [see comments], Nature 387,43-8. Hiebert, S. , Davis, I. , Downing, I. , Roussell, M. E, Gilliland, D. , et al. (1996). The t(12;21) translocation converts AML-l B from an activator to a re- 24 pressor of transcription, Molecular & Cellular Bio· logy 16, 1349-55. , Bae, S. , and Ito, Y. (1998). Cytoplasmic sequestration of the polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor alpha (CBFalpha) subunit by the leukemia- related PEBP2ICBFbeta-SMMHC fusion protein inhibits PEBP2/CBF-mediated transactivation, Mol Cell BioI 18, 4252-61.