ABC Transporters: Biochemical, Cellular, and Molecular by John N. Abelson, Melvin I. Simon, Suresh V. Ambudkar,

By John N. Abelson, Melvin I. Simon, Suresh V. Ambudkar, Michael M. Gottesman

The severely acclaimed laboratory normal for greater than 40 years, Methods in Enzymology is without doubt one of the so much hugely revered courses within the box of biochemistry. considering 1955, every one quantity has been eagerly awaited, usually consulted, and praised by way of researchers and reviewers alike. greater than 285 volumes were released (all of them nonetheless in print) and lots more and plenty of the fabric is correct even today-truly an important e-book for researchersin all fields of existence sciences.

Key Features
* Prokaryotic ABC Transporters
* Eukaryotic ABC Transporters
* Nonmammalian ABC delivery Systems
* Mammalian P-Glycoproteins
* Multidrug Resistance linked Protein
* Cystic Fibrosis Transmembrane Conductance Regulator
* Sulfonylurea Receptor
* Intracellular ABC Transporters

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00 [31 MALTOSETRANSPORTIN E. coli 31 the mechanism of these transporters, it is possible to speculate about the roles of the different c o m p o n e n t subunits. Role of Binding Proteins The strict correlation between the presence of a water-soluble or extrinsic ligand binding component and a signature A B C sequence in these transporters indicates that some fundamental aspect of the transport mechanism must rely on the BP. As we discuss in detail later, there is evidence that the binding protein has four potential functions: (1) binding the correct ligands to be transported, (2) communicating its state of occupancy to the m e m b r a n e components, (3) triggering the transport/ATPase cycle, and (4) delivering its ligand to the m e m b r a n e components.

Biophys. Acta 860, 44 (1986). 5~S. G. Kustu and G. -L. Ames, J. BacterioL 116, 107 (1973). 51R. Landick and D. L. Oxender, J. Biol. Chem. 260, 8257 (1985). 12 PROKARYOTIC ABC TRANSPORTERS [1] It has been demonstrated in various systems that mutations that inhibit the expression of the functional BP abolish the transport process. Thus BP is not only needed to increase the affinity and the specificity of the system, but also is essential for transport. Major progress was brought about by the isolation, by H.

A. Quiocho, Biochemistry 32, 10553 (1993). 46K. Gehring, P. G. Williams, J. G. Pelton, and D. E. Wemmer, Biochemistry 30, 5524 (1991). 47K. Gehring, K. Bao, and H. Nikaido, FEBS Lett. 300, 33 (1992). 48H. Nikaido, I. D. Pokrovskaya,L. Reyes, A. K. Ganesan, and J. A. Hall, in "Phosphate in Microorganisms: Cellular and Molecular Biology" (A. Torriani-Gorini, E. Yagil, and S. ), p. 91. ASM Press, Washington, DC, 1994. 4~T. Ferenci, M. -S. Lee, and D. Maris, Biochim. Biophys. Acta 860, 44 (1986). 5~S.

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